李双喜，博士/硕士生导师。山东大学齐鲁青年学者，山东省优青（海外），山东省泰山学者青年专家。2013年11月，华东师范大学生命医学研究所/德克萨斯大学西南医学中心，联合培养博士；2014年7月至2016年11月，德克萨斯大学西南医学中心，博士后；2016年12至2018年12 月，斯坦福大学医学院，博士后；2019年1月至2021年2月，斯坦福大学医学院，基础生命科学研究科学家；2021年3月至今，山东大学生命科学学院，研究员。
E-Mail：shuangxi@sdu.edu.cn
研究方向:
1. 神经退行性疾病C9-ALS的分子机制
2. 核糖体停滞和碰撞引发的翻译调控—核糖体相关质量控制（RQC）
3. 肠道干细胞自我更新与分化的分子机制
主持的科研项目:
山东大学齐鲁青年学者（2021.4-2026.3）
国家自然科学基金面上项目（2023.1-2026.12）
山东省优秀青年基金（海外）（2023.1-2025.12）
山东省青年泰山学者（2023.1-2025.12）
发表论文:
独立课题组成立后（通讯作者）：
1) Yu Li, Ji Geng, Suman Rimal, Haochuan Wang, Xiangguo Liu, Bingwei Lu, Shuangxi Li. The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD. J Biol Chem. 2023 Feb 8;102995
2) Ji Geng, Yu Li, Zhihao Wu, Suman Rimal, Rani Ohja, Shuangxi Li*, and Bingwei Lu*. A NOT4-ZNF598 axis responds to mitochondrial stress to quality control stalled translation and maintain tissue homeostasis. Nat Commun. 2023
3) Yu Li, Dongyue Liu, Haochuan Wang, Xuejing Zhang, Bingwei Lu, Shuangxi Li. The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila. Dev Biol. 2024
博士和博士后期间：
1)Shuangxi Li, Zhihao Wu, Ishaq Tantray, Yu Li, Songjie Chen, Jason Dong, Steven Glynn, Hannes Vogel, Michael Snyder, and Bingwei Lu. Quality control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Proc Natl Acad Sci. 2020 Sep 21; 202005506
2) Shuangxi Li#, Zhihao Wu#, Yu Li, Ishaq Tantray, Diego De Stefani, Andrea Mattarei, Fen-Biao Gao, Hannes Vogel, and Bingwei Lu. Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Cell Rep. 2020 Aug 4; 32(5):107989
3) Shuangxi Li#, Aiguo Tian#, Shuang Li#, Yuhong Han, Bing Wang, Jin Jiang. Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut. J Cell Biol. 2020 Apr 6; 219 (4).
4) Shuangxi Li#, Shuang Li#, Yuhong Han, Chao Tong, Bing Wang, Yongbin Chen, Jin Jiang. Regulation of Smo phosphorylation and high-level Hh signaling activity by a plasma membrane associated kinase. PLoS Biol. 2016 Jun 9;14(6)
5) Shuangxi Li#, Yong Suk Cho#,Tao Yue, Y Tony Ip, Jin Jiang. Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling. Cell Discov. 2015 Nov 24;1:15038
6) Shuangxi Li#, Cong Jiang#, Jingjing Pan, Xinbo Wang, Jiali Jin, Linlin Zhao, Weijuan Pan, Guanghong Liao, Xin Cai, Xiaotao Li, Jianru Xiao, Jin Jiang, Ping Wang. Regulation of c-Myc protein stability by proteasome activator REGgamma. Cell Death Differ. 2015 Jun;22(6):1000-11
7) Qi Li, Shuangxi Li, Sebastian Mana-Capelli, Rachel J. Roth Flach, Laura V. Danai, Alla Amcheslavsky, Yingchao Nie, Satoshi Kaneko, Xiaohao Yao, Xiaochu Chen, Jennifer L. Cotton, Junhao Mao, Dannel McCollum, Jin Jiang, Michael P. Czech, Lan Xu and Y. Tony Ip. The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell. 2014 Nov 10;31(3):291-304
8) Zoe H Davis, Laura Mediani, Francesco Antoniani, Jonathan Vinet, Shuangxi Li, Simon Alberti, Bingwei Lu, Alex S Holehouse, Serena Carra, Onn Brandman. Protein products of nonstop mRNA disrupt nucleolar homeostasis. Cell Stress Chaperones. 2021 Feb 22.
9) Suman Rimal, Yu Li, Rasika Vartak, Ji Geng, Ishaq Tantray, Shuangxi Li, Sungun Huh, Hannes Vogel, Charles Glabe, Lea T Grinberg, Salvatore Spina, William W Seeley, Su Guo, Bingwei Lu. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Acta Neuropathol Commun. 2021 Oct 18;9(1):169.
10) Shuang Li, Shuangxi Li, Bing Wang, Jin Jiang. Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases. Sci Signal. 2018 Feb 6;11(516).
11)Qing Shi, Shuang Li, Shuangxi Li, Alice Jiang, Yongbin Chen, Jin Jiang. Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Proc Natl Acad Sci. 2014 Dec 30;111(52):E5651-60
12) Shuang Li, Yong Suk Cho, Bing Wang, Shuangxi Li, Jin Jiang. Regulation of Smoothened Ubiquitylation and Cell Surface Expression Through a Cul4-DDB1-Gβ E3 Ubiquitin Ligase Complex. J Cell Sci. 2018 Aug 1;131(15)
13) Yong Suk Cho, Jian Zhu, Shuangxi Li, Bing Wang, Yuhong Han, Jin Jiang. Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K. Nat Commun. 2018 Apr 25;9(1):1657
14) Guoqiang Ma, Shuang Li, Yuhong Han, Shuangxi Li, Tao Yue, Bing Wang, Jin Jiang. Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway. Dev Cell. 2016 Nov 21;39(4):438-451.
15) Aiguo Tian, Qing Shi, Alice Jiang, Shuangxi Li, Bing Wang, and Jin Jiang. Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. J Cell Biol. 2015 Mar 16;208(6):807-19
16) Jinxia Sun, Yi Luan, Dong Xiang, Xiao Tan, Hui Chen, Qi Deng, Jiaojiao Zhang, Minghui Chen, Hongjun Huang, Weichao Wang, Tingting Niu, Wenjie Li, Hu Peng, Shuangxi Li, Lei Li, Wenwen Tang, Xiaotao Li, Dianqing Wu, Ping Wang. The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense Against Bacterial Pathogens. Cell Rep. 2016 Feb 2;14(4):737-749.
17) Ning Liu, Hui Li, Shuangxi Li, Mingyue Shen, Ning Xiao, Yunfei Chen, Yan Wang, Weichao Wang, Rui Wang, Qian Wang, Jianhua Sun, Ping Wang. The Fbw7/human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation Through Multiple Phosphodegron Motifs. J Biol Chem. 2010 Jun 11;285(24):18858-67.
