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微生物学

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杜良成

ldu3@unl.edu

教育背景

              起止时间                     毕业院校                    专业

博士  1993.9-1997.1 Royal Veterinary and Agricultural University   生物化学

硕士  1986.8-1989.7 中国科学院昆明植物研究所 生物化学

本科  1982.9-1986.7 云南大学生物系 生物学

工作经历

1997.1-2001.7   University of California, Davis      博士后

2001.8-2007.7   University of Nebraska-Lincoln       助理教授

2007.8-2013.7  University of Nebraska-Lincoln        副教授 (终身教职)

2013.8至今      University of Nebraska-Lincoln        教授

2011.9至今 山东大学生命学院 泰山学者海外特聘专家     (兼职)

科研方向

1. 新型生防细菌和内生真菌中的抗生素及活性天然产物

2. 天然产物的生物合成的分子机理, 代谢工程及合成生物学

3. 污染农产品和食品的真菌毒素的生物合成的分子机理

科研课题

1. NSFC海外及港澳学者合作研究基金 (31028019,2011.01-2012.12) 及连续资助(31329005,2014.01-2017.12),“溶杆菌的抗水稻病原菌活性成分分离和生物合成研究”

2. 973子课题(2013CB734002,2013.01-2017.12),“异源模块与生物底盘之间交互式作用的计算与预测” (子课题负责人之一)

3. NSFC重点项目 (81530091,2016.01-2020.12),“安莎的新骨架发掘与药用功能导向的结构优化” (课题骨干)

代表性论文

1. Zhao Y, Qian G, Ye Y, Wright S, Chen H, Shen Y, Liu F*, and Du L*. 2016. Heterocyclic aromatic N-oxidation in the biosynthesis of phenazine antibiotics from Lysobacter antibioticus. Organic Letters 18: 2495-2498.

2. Han Y, Wang Y, Tombosa S, Wright S, Huffman J, Yuen G, Qian G, Liu F, Shen Y*, and Du L*. 2015. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Applied Microbiology and Biotechnology 99: 801-811.  

3. Li Y, Chen H, Ding Y, Xie Y, Wang H, Cerny RL, Shen Y*, and Du L*. 2014. Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF. Angewandte Chemie International Edition 53: 7524-7530.

4. Wang Y, Qian G, Liu F, Li Y-Z, Shen Y, and Du L*. 2013. Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF. ACS Synthetic Biology 2: 670-678.

5. Wang Y, Qian G, Li Y, Wang YS, Wang YL, Wright S, Li Y-Z, Shen Y, Liu F, and Du L*. 2013. Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes. PLOS One 8(6): e66633.

6. Xie Y, Wright S, Shen Y, and Du L*. 2012. Bioactive natural products from Lysobacter. Natural Product Reports 29: 1277-1287.

7. Lou L, Chen H, Cerny RL, Li Y, Shen Y, and Du L*. 2012. Unusual activities of the thioesterase domain for the biosynthesis of the polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes C3. Biochemistry 51, 4-6.

8. Zhang W, Li Y, Qian G, Wang Y, Chen H, Li Y-Z, Liu F, Shen Y*, and Du L*. 2011. Identification and characterization of the anti-methicillin resistant Staphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11.Antimicrobial Agents and Chemotherapy 55: 5581-5589.

9. Lou L, Qian G, Xie Y, Hang J, Chen H, Zaleta-Rivera K, Li Y, Shen Y, Dussault PH, Liu F*, and Du L*. 2011. Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes. Journal of American Chemical Society 133: 643-645.

10. Du L* and Lou L. 2010. PKSs and NRPSs release mechanisms. Natural Product Reports 27: 255-278.

11. Gerber R, Lou L, and Du L*. 2009. A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides. Journal of American Chemical Society 131: 3148-3149.

12. Zhu X, Vogeler C, and Du L*. 2008. Functional complementation of fumonisin biosynthesis in FUM1-disrupted Fusarium verticillioides by the AAL-toxin polyketide synthase gene ALT1 from Alternaria alternata f. sp. Lycopersici. Journal of Natural Products 71:957-960.

13. Zhu X, Yu F, Li X-C, and Du L*. 2007. Production of dihydroisocoumarins in Fusarium verticillioides by swapping the ketosynthase domain of the fungal iterative modular polyketide synthase Fum1p with that of lovastatin diketide synthase. Journal of American Chemical Society 129: 36-37.

14. Yu F, Zaleta-Rivera K, Zhu X, Huffman J, Millet J, Harris SD, Yuen G, Li X, and Du L*. 2007. Structure and biosynthesis of HSAF, a broad spectrum antimycotic with a novel mode of action. Antimicrobial Agents and Chemotherapy 51: 64-72.

15. Zaleta-Rivera K, Xu C, Yu F, Butchko RAE, Proctor RH, Lara MEH, Raza A, Dussault PH, and Du L*. 2006. A bidomain nonribosomal peptide synthetase encoded by FUM14 catalyzes the formation of tricarballylic esters in the biosynthesis of fumonisins. Biochemistry 45: 2561-2569.


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