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微生物学

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谷立川

0531-88362039 lcgu@sdu.edu.cn
教育背景
1998/09-2002/08 中科院生物物理研究所,博士
1995/09-1998/07 在山东大学,化学学院,硕士
1991/09-1995/07 在山东大学,物理系获,学士
工作经历
2006/06-至今 山东大学,生命科学学院,微生物技术国家重点实验室,教授
2002/08-2006/06 普林斯顿大学,分子生物学系,博士后研究
研究方向
本实验室以结构生物学以及生物化学微生物学等技术手段致力于在分子水平上阐明重要病原微生物的关键代谢过程以及信号传导系统中相关蛋白质的结构与功能,为新型抗感染药物的研发提供必要的结构基础。同时与国家重点实验室其他课题组合作,系统地测定工业微生物中具有重要应用价值的酶的三维结构,并共同完成酶的理性改造。具体研究内容如下:
1.病原微生物铁代谢的分子机制;
2.病原与宿主以及与其他微生物相互作用的分子机制
3.病原菌生物膜形成与耐药性的分子机制
主持课题情况
1.山东省杰出青年基金,JQ201307,病原微生物蛋白质的结构与功能,2013/10-2016/10
2.教育部新世纪人才,NCET-12-0336,2013/01-2015/12
3.国家自然科学基金面上项目,3127078、YdiV与FliT通过与FlhD4C2 复合物作用负调控细菌鞭毛合成的分子机制,2013/01-2016/12
4.国家自然科学基金面上项目,31070655、微生物降解4-硝基酚途径中关键酶的结构与功能研究,2011/01-2013/12
5.国家自然科学基金青年基金,30800167、微生物脱硫途径酶的结构与功能研究及分子设计, 2009/1-2011/12
6.863 重大项目, 2006AA02A324,重要致病微生物蛋白质的结构研究2006/12-2011/12,490 万元
获得奖励情况
1.山东大学优秀教师2013
2.山东省杰出青年基金2013
3.教育部新世纪人才2012
代表性论文论著
1.Defen Lu, Guijun Shang, Heqiao Zhang, Qian Yu, Xiaoyan Cong,Jupeng Yuan, Fengjuan He, Chunyuan Zhu, Yanyu Zhao, Kun Yin, Yuanyuan Chen, Junqiang Hu, Xiaodan Zhang, Zenglin Yuan, Sujuan Xu,Wei Hu, Huaixing Cang, Lichuan Gu. Structural insights into T6SS effector protein Tse3 and Tse3-Tsi3 from Pseudomonas aeruginosa reveal a calcium-dependent and membrane-binding mechanism. Molecular Microbiology Jun;92(5):1092-112.
2.Shiheng Liu, Conggang Zhang, Tiantian Su, Tiandi Wei, Deyu Zhu, Kang Wang, Yan Huang, Yuhui Dong, Kun Yin, Sujuan Xu, Ping Xu and Lichuan Gu. Crystal structure of DszC from Rhodococcus sp. XP at 1.79 Å. Proteins 2014, Jan 28. doi: 10.1002/prot.24525.
3.Jing Su, Cong Zhang, Junjie Zhang, Tiandi Wei, Deyu Zhu, Ningyi Zhou, Lichuan Gu. Crystal structure of the γ-hydroxymuconic semialdehyde dehydrogenase from Pseudomonas sp. strainWBC-3, a key enzyme involved in para-Nitrophenol degradation. BMC Struct Biol. (2013) Nov 19;13:30.
4.Guijun Shang, Deyu Zhu, Ning Li, Junbing Zhang, Chunyuan Zhu, Defen Lu, Cuilan Liu, Qian Yu, Yanyu Zhao, Sujuan Xu, Lichuan Gu. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat Struct Mol Biol (2012) 19(7):725-7. 10.1038/nsmb.2332.
5.Wei Cheng, Kun Yin, Defen Lu, Bingqing Li, Deyu Zhu, Yuzhen Chen, Hao Zhang, Sujuan Xu, Jijie Chai, Lichuan Gu. Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state. Plos pathogens (2012) Mar;8(3):e1002528.
6.Ning Li, Conggang Zhang, Bingqing Li, Xiuhua Liu, Yan Huang, Sujuan Xu, Lichuan Gu.  Unique iron coordination in the iron-chelating molecule vibriobactin helps Vibrio cholera evade the mammalian siderocalin-mediated immune response. J. Biol. Chem. (2012), 287(12):8912-9.
7.Xiao-Liang Zhao, Di Sun, Tuo-Ping Hu, Shuai Yuan, Li-Chuan Gu, Heng-Jiang Cong, Hai-Yan He and Dao-Feng Sun. Phase transfer catalyst supported, room-temperature biphasic synthesis: a facile approach to the synthesis of coordination polymers. Dalton Trans., (2012), 41, 4320-3.
8.Xiuhua Liu, Qian Du, Zhi Wang, Shiheng Liu, Ning Li, Ying Chen, Chunyuan Zhu, Deyu Zhu, Tiandi Wei, Yan Huang, Sujuan Xu, Lichuan Gu. Crystal Structure of Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio cholerae at 1.7 Å Resolution. Febs Letter (2012) , 586(8):1240-4.
9.Liu Xiuhua, Gong Jing, Wei Tiandi, Wang Zhi, Du Qian, Zhu Deyu, Huang Yan, Xu Sujuan, Gu Lichuan. Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation. BMC Struct Biol. 2012 Sep 26;12:23.
10.Shiheng  Liu,  Conggang  Zhang,  Ning  Li,  Bei  Niu,  Mengyuan  Liu,  Xiuhua  Liu,  Tiandi  Wei,  Deyu  Zhu,  Yan  Huang,  Sujuan  Xu and Lichuan  Gu. Crystal structure of ISC binding ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot right before the enzymatic reaction. Acta Crystallogr D Biol Crystallography (2012), 68(Pt 10):1329-38.
11.Bingqing Li, Ning Li, Feng Wang, Liming Guo, Yan Huang, Xiuhua Liu, Tiandi Wei, Deyu Zhu, Cuilan Liu, Hongfang Pan, Sujuan Xu, Hong-Wei Wang, Lichuan Gu. Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility. Nucleic acid research (2012),40(21):11073-85.
12.Guijun Shang, Xiuhua Liu, Defen Lu, Junbing Zhang, Ning Li, Chunyuan Zhu, Shiheng Liu, Qian Yu, Yanyu Zhao, Heqiao Zhang, Junqiang Hu, Huaixing Cang, Sujuan Xu, Lichuan Gu. Structural insight into functioning of Pseudomonas aeruginosa peptidoglycan-hydolase Tse1 and its immunity protein Tsi1. Biochemical Journal (2012), 448(2):201-11.
13.Yong Gong, Deyu Zhu, Jingjin Ding, Chuan-Na Dou, Xiaoming Ren, Lichuan Gu, Tao jiang & Dacheng Wang. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5′-adenylated DNA. Nat Struct Mol Biol. (2011), 18(11), 1297-9.
14.Jing Su, Qiang Wang, Jinhong Feng, Cong Zhang, Deyu Zhu, Tiandi Wei, Wenfang Xu*, Lichuan Gu. Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development. Bioorg Med Chem. (2011),19(9), 2991-6.
15.Linjie Chen, Huayi Wang, Jie Zhang, Lichuan Gu, Niu Huang, Jian-Min Zhou & Jijie Chai. Structural basis for the catalytic mechanism of phosphothreonine lyase. Nature Structural & Molecular Biology. (2008), 15, 101 - 102
16.Min Hu, Lichuan Gu, Philip D. Jeffrey, and Yigong Shi. Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol. 2006 Feb;4(2):e27.
17.Liang Feng*, Suiping Zhou*, Lichuan Gu*, David A. Gell, Joel P. Mackay, Mitchell J. Weiss, Andrew J. Gow and Yigong Shi. Structure of oxidized -haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature. 2005 Jun 2;435(7042):697-701. (*These authors contributed equally).
18.Nieng Yan*, Lichuan Gu*, David Kokel*, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, and Yigong Shi. Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4. Mol Cell. 2004 Sep 24;15(6):999-1006. (*These authors contributed equally)
19.Eric N. Shiozaki, Lichuan Gu, Nieng Yan, and Yigong Shi. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell. 2004 May 7;14(3):405-12.
20.Lichuan Gu, Zhiqing Wang, Shiying Song, Yuyan Shu, Zhengjiong Lin. Crystal structures of an acidic phospholipase A(2) from the venom of Naja Kaouthia. Toxicon. (2002) 40(7):917-22.
21.Lichuan Gu, Hailong Zhang, Shiying Song, Yuancong Zhou, Zhengjiong Lin. Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus. Acta Crystallogr D Biol Crystallography. (2002) 58(Pt 1):104-10.
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