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微生物学

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徐海

86-0531-88362362 haixu@sdu.edu.cn

教育背景

博士    2000-2004              山东大学             微生物学

硕士    1996-1999              山东大学             微生物学

本科    1987-1982              复旦大学             微生物学

工作经历

1982-1992      江苏省微生物研究所           助理研究员

1992-至今      山东大学生命科学学院         教授(2007.9聘任)

2004-2007      哥伦比亚大学                 博士后

科研方向

1.微生物遗传和生理

2.微生物发酵

3.微生物基因组学

主持课题

1. 2011.09-2012.12   从环境污水中分离鉴定细菌质粒上与整合子相关的耐药基因,山东省医药卫生科技发展计划项目

2. 2012.01-2015.12  质粒介导的喹诺酮类耐药性基因在环境污水中传播及相关耐药肠道细菌的遗传结构分析, 国家自然基金面上项目

3. 2013.01-2017.12  微生物发酵法高效生产L-精氨酸技术的开发与应用,企业项目

4.2010/2011/2013  环境整合子细菌的鉴定 耐药基因功能及其转移机制,微生物技术国家重点实验室项目

5.2013.01-2015.12   肉鸡产业链超耐药菌的耐药基因及转移性分析,国家科技重大专项

论文  

1. Wu, H., M.Y. Wang, Y.Q. Liu, X.H. Wang, Y.K. Wang, J.X. Lu and H. Xu*. 2016. Characterization of antimicrobial resistance in Klebsiella species isolated from chicken broilers. Int. J. Food Microbiol. 232:95-102.

2. Wu, H., S.B. Xia, F.Y. Bu, J. Qi, Y.Q. Liu and H. Xu*. 2015. Identification of integrons and phylogenetic groups of drug-resistant Escherichia coli from broiler carcasses in China. Int. J. Food Microbiol. 211: 51–56.

3. Xia, R., Y. Ren, X. H. Guo and H. Xu*. 2013. Molecular diversity of class 2 integrons in antibiotic-resistant gram-negative bacteria found in wastewater environments in China. Ecotoxicology. 22: 402-414.

4. Xia, R., Y. Ren and H. Xu*. 2013. Identification of Plasmid-Mediated Quinolone Resistance qnr Genes in Multidrug-Resistant Gram-Negative Bacteria from Hospital Wastewaters and Receiving Waters in the Jinan Area, China. Microb Drug Resist. 19: 446-456.

5. Han, N., D.H. Sheng and H. Xu*. 2012. Role of Escherichia coli strain subgroups, integrons, and integron-associated gene cassettes in dissemination of antimicrobial resistance in aquatic environments of Jinan, China. Water Sci Technol. 66: 2385-2392.

6. Guo ¹, X.H., R. Xia ¹, N. Han and H. Xu*. 2011. Genetic diversity analyses of class 1 integrons and their associated antimicrobial resistance genes in Enterobacteriaceae strains recovered from aquatic habitats in China. Lett Appl Microbiol. 52: 667–675.

7. Xu, H*., K. Broersma, V. Miao and J. Davies. 2011. Class 1 and Class 2 integrons in multidrug resistant Gram-negative bacteria isolated from the Salmon River, British Columbia. Can J Microbiol. 57: 460-467.

8. Xu, H*., V. Miao, W. Kwong, R. Xia and J. Davies. 2011. Identification of a Novel Fosfomycin Resistance Gene (fosA2) in Enterobacter cloacae from the Salmon River, Canada. Lett Appl Microbiol. 52: 427–429

9. Xia, R., X.H. Guo, Y.Z. Zhang and H. Xu*. qnrVC-Like Gene Located in a Novel Complex Class 1 Integron Harboring the ISCR1 Element in an Aeromonas punctata Strain from an Aquatic Environment in Shandong Province, China. Antimicrob Agents Chemother. 2010; 54(8): 3471-3474.

10. Xu, H., J. Davies and M. Vivian*. 2007. Molecular Characterization of Class 3 Integrons from Delftia spp. J Bacteriol. 189: 6276-6283. Xu, H., Y. Z. Zhang, X. K. Guo, S. X. Ren, A. A. Staempfli, J. S. Chiao, W. H. Jiang, G. P. Zhao. 2004. Isoleucine biosynthesis in Leptospira interrogans serotype lai strain #56601 proceeds via a threonine-independent pathway   J Bacteriol. 183: 5400-5409.  

专利  

1. 发明人:徐海,国宪虎,夏蕊蕊. 2013. 专利名称:利用EcoRII酶切图谱库检测细菌整合子中基因盒阵列的方法. 专利号:01110080541.6 发文日:2013.09.18

实验室网站

http://www.mbtech.sdu.edu.cn/xulab/index/index.html 

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