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微生物学

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高超

88364003 jieerbu@sdu.edu.cn

教育背景

博士    2004.09-2009.12         山东大学               发酵工程

本科    2000.09-2004.06         山东大学               生物技术

工作经历

2009.12-2011.12                 上海交通大学           博士后

2012.02-                        山东大学              副教授、博士生导师

科研方向

1. 微生物生理与生化

2. 生物催化

3. 合成生物学

主持课题

1. 2015.01-2018.12,恶臭假单胞菌中一条新的戊二酸代谢途径,国家自然科学基金面上项目

2. 2014.07-2016.12,赖氨酸生物转化生产5-氨基戊酸,国家高技术研究发展计划    

3. 2013.01-2016.12,新型NAD非依赖性D-乳酸脱氢酶催化机理及应用基础研究,国家自然科学基金面上项目

4. 2012.11-2015.12,2-丁醇工程菌的基因组规模系统代谢育种,国家高技术研究发展计划

5. 2013.01-2015.12,基于芽孢表面展示系统构建乳酸生物传感器,山东省优秀中青年科学家奖励基金

6. 2010.06-2011.12,生物催化法高效生产手性2-羟基丁酸,中国博士后科学基金面上项目

7. 2011.01-2011.12,洋葱伯克霍尔德菌新型NAD非依赖性L-乳酸脱氢酶研究,中国博士后科学基金特别资助

8. 2015.07-2020.06,铜绿假单胞菌L-乳酸代谢关键酶调控机制,山东大学青年学者未来计划

研究成果

1. Ge Yongsheng, Li Kun, Li Lixiang, Gao Chao*, Lijie Zhang, Ma Cuiqing, Xu Ping, Contracted but effective: production of enantiopure 2,3-butanediol by thermophilic and GRAS Bacillus licheniformis. Green Chem, 2016, accepeted. SCI, IF= 8.532

2. Binbin Sheng, Jing Xu, Yongsheng Ge, Shuo Zhang, Danqi Wang, Chao Gao*, Cuiqing Ma, Ping Xu. Enzymatic Resolution by a d-Lactate Oxidase Catalyzed Reaction for (S)-2-Hydroxycarboxylic Acids. ChemCatChem 2016, 8, 2630 – 2633, SCI, IF= 5.107

3. Yingxin Zhang, Tianyi Jiang, Binbin Sheng, Yangdanyu Long, Chao Gao*, Cuiqing Ma, Ping Xu. Coexistence of two D-lactate-utilizing systems in Pseudomonas putida KT2440. Environmental Microbiology Reports 2016, doi:10.1111/1758-2229.12429. SCI, IF= 3.517

4. Zhong Li, Jing Xu, Tongtong Jiang, Yongsheng Ge, Pan Liu, Manman Zhang, Zhiguo Su, Chao Gao*, Cuiqing Ma, Ping Xu. Overexpression of transport proteins improves the production of 5-aminovalerate from l-lysine in Escherichia coli. Sci Rep, 2016, 6, 30884, SCI, IF=5.597

5. Gao Chao, Li Zhong, Zhang Lijie, Wang Chao, Li Kun, Ma Cuiqing, Xu Ping, An artificial enzymatic reaction cascade for a cell-free bio-system based on glycerol, Green Chem, 2015, 17, 804-807, SCI, IF= 8.532

6. Chu Haipei , Xin Bo, Liu Peihai, Wang Yu, Li Lixiang, Liu Xiuxiu, Zhang Xuan, Ma Cuiqing, Xu Ping, Gao Chao*, Metabolic engineering of Escherichia coli for production of (2S,3S)-butane-2,3-diol from glucose, Biotechnol Biofuels, 2015, 8, 143, SCI, IF= 7.398

7. Wang Yujiao, Zhang Yingxin, Jiang Tianyi, Meng Jingjing, Sheng Binbin, Yang Chunyu, Gao Chao*, Xu Ping, Ma Cuiqing, A novel biocatalyst for efficient production of 2-oxo-carboxylates using glycerol as the cost-effective carbon source. Biotechnol Biofuels, 2015, 8, 186, SCI, IF= 7.398

8. Zhang Lijie, Zhang Yingxin, Liu Qiuyuan, Meng Liying, Hu Mandong, Lv Min, Li Kun, Gao Chao*, Xu Ping, Ma Cuiqing, Production of diacetyl by metabolically engineered Enterobacter cloacae. Sci Rep, 2015, 5, 9033, SCI, IF=5.597

9. Gao Chao, Wang Yujiao, Zhang Yingxin, Lv Min, Dou Peipei, Xu Ping, Ma Cuiqing, NAD-Independent L-lactate dehydrogenase required for L–lactate utilization in Pseudomonas stutzeri A1501. J. Bacteriol, 2015, 197, 2239–2247, SCI, IF=3.11

10. Sheng Binbin, Xu Jing, Zhang Yingxin, Jiang Tianyi, Deng Sisi, Kong Jian, Gao Chao, Ma Cuiqing, Xu Ping, Utilization of D-lactate as an energy source supports the growth of Gluconobacter oxydans, Appl Environ Microbiol. 2015, 81, 4098-4110, SCI, IF=4.359

11. Wang Yujiao, Lv Min, Zhang Yingxin, Xiao Xieyue, Jiang Tianyi, Zhang Wen, Hu Chunhui, Gao Chao*, Ma Cuiqing, Xu Ping, Reconstruction of lactate utilization system in Pseudomonas putida KT2440: a novel biocatalyst for L -2-hydroxy-carboxylate production, Sci Rep, 2014, 4, 6939, SCI, IF=5.597

12. Wang Xiuqing, Lv Min, Zhang Lijie, Li Kun, Gao Chao*, Ma Cuiqing, Xu Ping, Efficient bioconversion of 2,3-butanediol into acetoin using Gluconobacter oxydans DSM 2003, Biotechnol Biofuels, 2013, 6, 155, SCI, IF= 7.398

13. Gao Chao, Wang Xiuqing, Ma Cuiqing, Xu ping, Production of hydroxypyruvate from glycerate by a novel biotechnological route, Bioresour Technol, 2013, 131, 552-4, SCI, IF=5.33

14. Gao Chao, Zhang Lijie, Xie Yingjian, Hu Chunhui, Zhang Yue, Li Lixiang, Wang Yu, Ma Cuiqing, Xu Ping, Production of (3S)-acetoin from diacetyl by using stereoselective NADPH-dependent carbonyl reductase and glucose dehydrogenase, Bioresour Technol, 2013, 137, 111–115, SCI, IF=5.33

15. Gao Chao, Hu Chunhui, Zheng Zhaojuan, Ma Cuiqing, Jiang Tianyi, Dou Peipei, Zhang Wen, Che Bin, Wang Yujiao, Lv Min, Xu Ping, Regulation of lactate utilization by the FadR-type regulator LldR in Pseudomonas aeruginosa, J. Bacteriol, 2012, 194, 2687–2692, SCI, IF=3.11

16. Gao Chao, Zhang Wen, Huang Yuanli, Ma Cuiqing, Xu Ping , Efficient conversion of 1,2-butanediol to (R)-2-hydroxybutyric acid using whole cells of Gluconobacter oxydans, Bioresour Technol, 2012, 115, SCI, IF=5.33

17. Gao Chao, Ma Cuiqing, Xu Ping, Biotechnological routes based on lactic acid production from biomass, Biotechnol Adv, 2011, 29, 930-939, SCI, IF= 11.885

18. Gao Chao, Zhang Wen, Ma Cuiqing, Liu Peng, Xu Ping, Kinetic resolution of 2-hydroxybutanoate racemic mixtures by NAD-independent L-lactate dehydrogenase, Bioresour Technol, 2011, 102, 4595-4599, SCI, IF=5.33

19. Gao Chao, Xu Xiaoman, Zhang Xifeng, Che Bin, Ma Cuiqing, Qiu Jianhua, Tao Fei, Xu Ping, Chemoenzymatic Synthesis of N-Acetyl-D-Neuraminic Acid from N-Acetyl-D-Glucosamine by Using the Spore Surface-Displayed N-Acetyl-D-Neuraminic Acid Aldolase, Appl Environ Microbiol. 2011, 77, 7080-7083, SCI, IF=4.359



 

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